Simple Tutorial:
1. Copy Interface.dylib to the install directory.
2. Add "127.0.0.1	api.simplify3d.com" to /etc/hosts for disabling Login.
3. Run "DYLD_INSERT_LIBRARIES=./Interface.dylib DYLD_FORCE_FLAT_NAMESPACE=1 ./Simplify3D.app/Contents/MacOS/Simplify3D".
4. Run "DYLD_INSERT_LIBRARIES=./Interface.dylib:/System/Library/Frameworks/OpenGL.framework/Resources/GLEngine.bundle/GLEngine DYLD_FORCE_FLAT_NAMESPACE=1 ./Simplify3D.app/Contents/MacOS/Simplify3D" if the error "dyld: lazy symbol binding failed: Symbol not found: _gliCreateContextWithShared" happens.

Detailed Tutorial:
1) Install Simplify3D as normal using the OS X folder. This will create a folder in your Application folder that is called Simpify3D or something similar. If it the folder is not named Simplify3D, rename it.
2) Go into the patch files and you will find "Interface.dylib" within the OS X patch folder. There is a read me in there, but it is not in depth. I will explain that process next.
3) Copy "Interface.dylib" to the Simplify3D folder we created above when installing it into Applications.
4) Open Terminal. Type in: "sudo nano /etc/hosts" (without quotes), this will allow you to edit your hosts so you can add "127.0.0.1 api.simplify3d.com" (without quotes). Once this is added below the other items listed in the hosts, press Control + X to exit, Press Y to save changes, then press Return to confirm the changes.
5) In Terminal, type "cd /Applications/Simplify3D" without quotes, this tells terminal to use that folder for the commands we are going to tell it next.
6) Type or copy/paste into terminal: 
DYLD_INSERT_LIBRARIES=./Interface.dylib DYLD_FORCE_FLAT_NAMESPACE=1 ./Simplify3D.app/Contents/MacOS/Simplify3D
Then press return. If you followed the steps above correct, Simplify3D should launch without issue.

[Now this next step is OPTIONAL, but unless you want to open terminal each time you run this app, then you will find it helpful.]
7) Close Terminal and Simplify3D, if open We will not need them anymore. Now open up Automator, you will find this within Applications. Select File > New in the menu bar and select Application when the window pops up.
8) On the left hand side, search for "Run Shell Script". Then drag and drop that option to the right side that has a grey background.
9) In the new window that says "Run Shell Script", delete the word "cat" and type in BOTH of the lines listed, with a space as it is shown below:
cd /Applications/Simplify3D DYLD_INSERT_LIBRARIES=./Interface.dylib DYLD_FORCE_FLAT_NAMESPACE=1 ./Simplify3D.app/Contents/MacOS/Simplify3D
10) Now select Run in the top right, this is just to test this "app" to make sure it works. If Simplify3D loaded, then you are in business. Don't stop yet though, we have one last step.
11) In Automator, select File > Save. I saved my application as "Simplify3d - Launcher" but feel free to use anything you like as long as you do not leave it as "Simplify3D" as there is another app already (the actual app, not the one we are creating). For "Where", navigate to the Simplify3D folder in Applications that we created in step 1 during installation.
12) Save the Application. Now whenever you need to use Simplify3D, run the Simplify3D - Launcher (Or whatever you named it) and Simplify3D will start up as if you had a license.
Hope that helped out.

I have yosemite installed on my mac, and to be able to eject replace the text to be pasted from steps 6 and 9 with the text from step 4 of the simple tutorial, once you correct the window appears for logger, locks and run the program

#VirusTotal
Interface.dylib                                              www.virustotal.com/#/file/b41f903fed50989c62179d126da7c445e1e59a1ddedd9e140ae55926c25cccd0
Simplify3D-4.0.1-osx-installer.zip              www.virustotal.com/#/file/123f6b0f300612f93fcf856724849c255575b6e131c3fc2d97256906714a1a44